Endocrine Myopathies: Clinical Review

Lipid storage myopathies with unusual clinical manifestations.

We describe the clinical presentation, course and pathologic findings found in three adult patients with lipid storage myopathy. Excessive lipid storage was found in Type 1 fibers of muscle. Clinical improvement on oral levo-carnitine therapy suggests the possibility of carnitine deficiency as the most likely etiology in two of the patients and one had mitochondrial myopathy confirmed on geneti...

Mitochondria 1 myopathies : clinical defects 523

The mitochondrial myopathies are a clinically heterogeneous group o f diseases characterized by abnormal mitochondrial proliferation in skeletal muscle and in other affected cells [ 1, 2 ) . Studies of mitochondrial metabolism in vitro in over I00 published cases have identified a number of different functional defects which have mostly involved the oligomeric complexes of the mitochondria1 res...

Statin myopathies: pathophysiologic and clinical perspectives.

Idiopathic Inflammatory Myopathies: Clinical Approach and Management

Idiopathic inflammatory myopathies (IIM) are a group of chronic, autoimmune conditions affecting primarily the proximal muscles. The most common types are dermatomyositis (DM), polymyositis (PM), necrotizing autoimmune myopathy (NAM), and sporadic inclusion body myositis (sIBM). Patients typically present with sub-acute to chronic onset of proximal weakness manifested by difficulty with rising ...

Recent clinical trials in idiopathic inflammatory myopathies.

PURPOSE OF REVIEW Idiopathic inflammatory myopathies (IIMs) are complex multisystemic autoimmune diseases. Glucocorticoids remain the cornerstone of treatment in IIM, and the benefit of additional immunosuppressors is still debated. A limited number of controlled clinical trials have been available to support treatment guidelines, but in the last year, several clinical trials have been publishe...